The Ethics of Clinical Trials Research in Severe Mood Disorders

Bioethics. May 2017. doi:10.1111/bioe.12349
Authors: Nugent, A. C., Miller, F. G., Henter, I. D. and Zarate, C. A.
“Mood disorders, including major depressive disorder (MDD) and bipolar disorder (BD), are highly prevalent, frequently disabling, and sometimes deadly. Additional research and more effective medications are desperately needed, but clinical trials research in mood disorders is fraught with ethical issues. Although many authors have discussed these issues, most do so from a theoretical viewpoint. This manuscript uses available empirical data to inform a discussion of the primary ethical issues raised in mood disorders research.”
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